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2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate

Tenofovir disoproxil fumarate

CAS: 202138-50-9

Molecular Formula: C23H34N5O14P

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  5. 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate - Names and Identifiers

Name Tenofovir disoproxil fumarate
Synonyms Aids031697
Aids-031697
Bis(neopentyloc)pmpa
Tenofovir disoproxil fumarate
Tenofovir diisoproxil fuMarate
Tenofovir dipivoxil FuMarate(TDF)
Tenofovir Disoproxil Fumarate (200 mg)
9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate
bis({[(1-methylethoxy)carbonyl]oxy}methyl) {[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonate (2E)-but-2-enedioate
2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-
2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate
CAS 202138-50-9
EINECS 687-766-5
InChI InChI=1/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate - Physico-chemical Properties

Molecular FormulaC23H34N5O14P
Molar Mass635.52
Melting Point113-115°C
Boling Point642.7°C at 760 mmHg
Flash Point342.5°C
Solubility DMSO (Slightly), Methanol (Slightly)
Vapor Presure2.06E-16mmHg at 25°C
AppearanceWhite to pink crystals
Colorwhite to beige
Storage Condition2-8°C
In vitro studyThe circulation of Tenofovir is actively secreted by the kidneys through glomerular filtration and renal tubules. Tenofovir is not a substrate for human organic cation transport type 1 (hOCT1) or hoct2. In MRP4 overexpressing cells, Tenofovir accumulates to five-fold lower levels, and MRP inhibitors can increase its accumulation. Tenofovir does not significantly affect mitochondrial DNA(mtDNA) in human hepatoblastoma (HCC) cells, skeletal muscle cells (SkMCs) or renal proximal tubule epithelial cells. In HepG2 cells or SkMCs, Tenofovir increased lactate production by less than 20%. Tenofovir is a potent phosphorylation of Tenofovir diphosphate (TFV-DP) in HepG2 cells and human primary hepatocytes. In the cell-based assay, the 50% effective concentration of Tenofovir anti-HBV was 1.1 mM, with a 50-fold increase in efficiency after the addition of the pre-bis-isoproxil group. In Vitro and clinically, Tenofovir has full activity against lamivudine-resistant HBV. Tenofovir inhibited the proliferation of hepatogenic hepatocellular carcinoma cells and normal skeletal muscle cells with CC(50) values of 398 μm and 870 μm, respectively. Tenofovir has a weaker effect than cidofovir on the proliferation and viability of renal proximal tubular epithelial cells, and cidofovir has a potential related nucleotide analog to induce renal tubular dysfunction.

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
HS Code2933599550

2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate - Reference

Reference
Show more
1. Yan Pengfei, Cui Yixuan, Liu Di et al.. Determination of 9-propenyladenine in tenofovir disoproxil fumarate by dispersion liquid-liquid microextraction combined with HPLC [J]. Analysis Laboratory 2019 v.38(12):58-61.
2. [IF = 3.414] Qing Zhao et al."Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: in vivo and in vitro studies." J Ethnopharmacol. 2019 Nov;244:112132
2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate
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Email: r@reformchem.com­
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MedChemExpress (MCE)
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CAS: 202138-50-9
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Tenofovir disoproxil fumarate Request for quotation
CAS: 202138-50-9
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Email: pules.cn@gmail.com
Mobile: +86-17551318830
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Product Name: Tenofovir disoproxil fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
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Email: sales@chinaskyrun.com
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QQ: 2531159185 Click to send a QQ messageSend QQ message
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CAS: 202138-50-9
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CAS: 202138-50-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 202138-50-9
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Email: 3008007409@qq.com
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View History
2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate
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